Issue 21, 2009
From the journal:

Organic & Biomolecular Chemistry

Hydrolytic activity of histidine-containing octapeptides in water identified by quantitative screening of a combinatorial library†

Carsten Schmuck,*a   Ute Michelsa  and  Jürgen Dudaczeka  

* Corresponding authors

a Institute of Organic Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, Germany
E-mail: carsten.schmuck@uni-due.de
Fax: +49 201 1834259
Tel: +49 201 183 3097

Abstract

A quantitative on-bead screening of a combinatorial octapeptide library revealed catalysts with hydrolytic activity in water. Histidine is an essential amino acid but the catalytic activity as well as the substrate binding affinity is also dependent on the sequence of the octapeptide.

Graphical abstract: Hydrolytic activity of histidine-containing octapeptides in water identified by quantitative screening of a combinatorial library

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Article information

DOI
https://doi.org/10.1039/B904415A
Article type
Paper
Submitted
04 Mar 2009
Accepted
02 Jul 2009
First published
19 Aug 2009

Org. Biomol. Chem., 2009,7, 4362-4368

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Hydrolytic activity of histidine-containing octapeptides in water identified by quantitative screening of a combinatorial library

C. Schmuck, U. Michels and J. Dudaczek, Org. Biomol. Chem., 2009, 7, 4362 DOI: 10.1039/B904415A

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