Complementary chemoenzymatic routes to both enantiomers of febrifugine†
Abstract
Two complementary strategies for the synthesis of febrifugine are detailed based on previously developed chemoenzymatic approaches to the
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* Corresponding authors
a
Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, The Netherlands
E-mail:
F.Rutjes@science.ru.nl
Fax: +31 24 365 3393
Tel: +31 24 365 3202
b Chiralix B.V., P.O. Box 31070, The Netherlands
c DSM Pharma Products, P.O. Box 18, The Netherlands
Two complementary strategies for the synthesis of febrifugine are detailed based on previously developed chemoenzymatic approaches to the
M. A. Wijdeven, R. J. F. van den Berg, R. Wijtmans, P. N. M. Botman, R. H. Blaauw, H. E. Schoemaker, F. L. van Delft and F. P. J. T. Rutjes, Org. Biomol. Chem., 2009, 7, 2976 DOI: 10.1039/B901670H
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