Issue 14, 2009
From the journal:

Organic & Biomolecular Chemistry

Complementary chemoenzymatic routes to both enantiomers of febrifugine†

Marloes A. Wijdeven,a   Rutger J. F. van den Berg,a   Roel Wijtmans,a   Peter N. M. Botman,b   Richard H. Blaauw,b   Hans E. Schoemaker,c   Floris L. van Delfta  and  Floris P. J. T. Rutjes*a  

* Corresponding authors

a Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, The Netherlands
E-mail: F.Rutjes@science.ru.nl
Fax: +31 24 365 3393
Tel: +31 24 365 3202

b Chiralix B.V., P.O. Box 31070, The Netherlands

c DSM Pharma Products, P.O. Box 18, The Netherlands

Abstract

Two complementary strategies for the synthesis of febrifugine are detailed based on previously developed chemoenzymatic approaches to the 3-hydroxypiperidine skeleton. The introduction of the quinazolone-containing side chain in both strategies was based on an N-acyliminium ion-mediated coupling reaction.

Graphical abstract: Complementary chemoenzymatic routes to both enantiomers of febrifugine

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B901670H
Article type
Paper
Submitted
26 Jan 2009
Accepted
30 Apr 2009
First published
04 Jun 2009

Org. Biomol. Chem., 2009,7, 2976-2980

Permissions

Request permissions

Complementary chemoenzymatic routes to both enantiomers of febrifugine

M. A. Wijdeven, R. J. F. van den Berg, R. Wijtmans, P. N. M. Botman, R. H. Blaauw, H. E. Schoemaker, F. L. van Delft and F. P. J. T. Rutjes, Org. Biomol. Chem., 2009, 7, 2976 DOI: 10.1039/B901670H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements