Issue 11, 2009

A general strategy for the preparation of C-terminal peptide α-ketoacids by solid phase peptide synthesis

Abstract

A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide α-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide α-ketoacids with unprotected side chains is reported.

Graphical abstract: A general strategy for the preparation of C-terminal peptide α-ketoacids by solid phase peptide synthesis

Supplementary files

Article information

Article type
Communication
Submitted
20 Jan 2009
Accepted
25 Mar 2009
First published
02 Apr 2009

Org. Biomol. Chem., 2009,7, 2259-2264

A general strategy for the preparation of C-terminal peptide α-ketoacids by solid phase peptide synthesis

L. Ju and J. W. Bode, Org. Biomol. Chem., 2009, 7, 2259 DOI: 10.1039/B901198F

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