Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-O-acyl glucuronides†‡
Abstract
Many widely-used non-steroidal anti-inflammatory agents (NSAIDs), e.g.
* Corresponding authors
a
Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool, UK
E-mail:
stachuls@liv.ac.uk
Fax: +44(0)151 794 3588
Tel: +44(0)151 794 3542
b Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington, London, UK
c DMPK, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, UK
Many widely-used non-steroidal anti-inflammatory agents (NSAIDs), e.g.
N. G. Berry, L. Iddon, M. Iqbal, X. Meng, P. Jayapal, C. H. Johnson, J. K. Nicholson, J. C. Lindon, J. R. Harding, I. D. Wilson and A. V. Stachulski, Org. Biomol. Chem., 2009, 7, 2525 DOI: 10.1039/B822777B
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