Issue 9, 2009
From the journal:

Organic & Biomolecular Chemistry

Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane†

Andrei V. Malkov,‡*a   Marek Figlus,a   Graeme Cooke,*a   Stuart T. Caldwell,a   Gouher Rabani,a   Mark R. Prestlya  and  Pavel Kočovský*a  

* Corresponding authors

a WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK
E-mail: A.Malkov@lboro.ac.uk, graemec@chem.gla.ac.uk, pavelk@chem.gla.ac.uk

Abstract

Gold nanoparticles functionalised with a valine-derived formamide have been developed as effective homogenous catalysts for the asymmetric reduction of ketimine 1 with trichlorosilane (≤84% ee) in toluene. This methodology both simplifies the recovery of the catalyst and its separation from the product, as the nanoparticles can be readily removed and subsequently recycled by precipitation from the reaction mixture.

Graphical abstract: Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane

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Article information

DOI
https://doi.org/10.1039/B821391G
Article type
Paper
Submitted
28 Nov 2008
Accepted
06 Feb 2009
First published
25 Mar 2009

Org. Biomol. Chem., 2009,7, 1878-1883

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Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane

A. V. Malkov, M. Figlus, G. Cooke, S. T. Caldwell, G. Rabani, M. R. Prestly and P. Kočovský, Org. Biomol. Chem., 2009, 7, 1878 DOI: 10.1039/B821391G

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