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Issue 10, 2009
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Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}

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Abstract

Micellar mannose nanoparticles were constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]} with fluorophores or quenchers doped into the hydrophobic inner cores, allowing the direct monitoring of multivalent lectin–glycan interactions. The mannose-displaying nanoparticles bind Con A and sperm surface lectins with high affinity, suggesting their broad utility for modulating proteincarbohydrate interaction mediated cell surface biology.

Graphical abstract: Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}

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Article information


Submitted
10 Oct 2008
Accepted
04 Dec 2008
First published
17 Mar 2009

Org. Biomol. Chem., 2009,7, 2040-2045
Article type
Paper

Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}

R. Su, L. Li, X. Chen, J. Han and S. Han, Org. Biomol. Chem., 2009, 7, 2040
DOI: 10.1039/B817823B

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