Issue 2, 2009
From the journal:

Organic & Biomolecular Chemistry

Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst†

François-Moana Gautier,a   Simon Jones*a  and  Stephen J. Martinb  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Dainton Building, Brook Hill, Sheffield, UK
E-mail: simon.jones@sheffield.ac.uk
Fax: +44 (0)114 2229346
Tel: +44 (0)114 2229483

b Aesica Pharmaceuticals Ltd., Windmill Industrial Estate, Shotton Lane, Cramlington, Northumberland, UK

Abstract

Organocatalysts for the asymmetric reduction of ketimines are presented that function well at low catalyst loadings providing chiral amines in good yield and enantioselectivity, the latter appearing to be independent of the ketimine substrate geometry.

Graphical abstract: Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst

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Article information

DOI
https://doi.org/10.1039/B816051A
Article type
Communication
Submitted
17 Sep 2008
Accepted
30 Oct 2008
First published
19 Nov 2008

Org. Biomol. Chem., 2009,7, 229-231

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Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst

F. Gautier, S. Jones and S. J. Martin, Org. Biomol. Chem., 2009, 7, 229 DOI: 10.1039/B816051A

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