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Issue 5, 2009
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Interactions between dendrimers and heparin and their implications for the anti-prion activity of dendrimers

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Abstract

Heparin is involved in the pathogenesis of prion diseases, affecting the process of fibril formation. It has been shown that whether it accelerates or inhibits fibrilogenesis depends on its concentration: prion peptide PrP 185-208 aggregates in the presence of 0.04 mg ml−1 heparin, but concentrations ten times lower or higher cause no aggregation. Polyamidoamine, polypropyleneimine and phosphorus dendrimers that previously exhibited anti-prion activity have been shown to interact with heparin. The interactions between cationic dendrimers and anionic heparin are mainly electrostatic. The present study shows that these interactions are indirectly responsible for the inhibition or enhancement of fibril formation by dendrimers.

Graphical abstract: Interactions between dendrimers and heparin and their implications for the anti-prion activity of dendrimers

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Publication details

The article was received on 18 Nov 2008, accepted on 14 Jan 2009 and first published on 10 Feb 2009


Article type: Paper
DOI: 10.1039/B820632P
Citation: New J. Chem., 2009,33, 1087-1093
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    Interactions between dendrimers and heparin and their implications for the anti-prion activity of dendrimers

    B. Klajnert, M. Cangiotti, S. Calici, M. Ionov, J. P. Majoral, A. Caminade, J. Cladera, M. Bryszewska and M. F. Ottaviani, New J. Chem., 2009, 33, 1087
    DOI: 10.1039/B820632P

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