Issue 9, 2009
From the journal:

New Journal of Chemistry

Immunomodulatory effects of functionalised chalcones on pro-inflammatory cytokine release from lung epithelial cells†

Nicole Maria Smith,a   Pengkai Soh,b   Nithiananthan Asokananthan,b   Marck Norret,a   Geoffrey A. Stewart*b  and  Colin Llewellyn Raston*a  

* Corresponding authors

a Centre for Strategic Nano-Fabrication, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Australia
E-mail: colin.raston@uwa.edu.au
Fax: +61 8 6488 8683
Tel: +61 8 6488 3045

b School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Australia
E-mail: gashos@cyllene.uwa.edu.au
Fax: +61 8 6488 7330
Tel: +61 8 6488 4699

Abstract

Chalcones, prepared in high yield in polyethylene glycol, Mw = 300 (PEG300), were screened for inhibition of the thrombin-mediated release of pro-inflammatory interleukin-6 (IL-6) and interleukin-8 (IL-8) from the A549 lung epithelial cell line. Several show significant down-regulation of these pro-inflammatory mediators in a dose-dependant manner with one exhibiting pro-inflammatory properties. Computational studies on selected chalcones revealed a detailed understanding of the structure, electron density and biological activity relationship.

Graphical abstract: Immunomodulatory effects of functionalised chalcones on pro-inflammatory cytokine release from lung epithelial cells

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Article information

DOI
https://doi.org/10.1039/B909172F
Article type
Paper
Submitted
08 May 2009
Accepted
22 Jun 2009
First published
14 Jul 2009

New J. Chem., 2009,33, 1869-1873

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Immunomodulatory effects of functionalised chalcones on pro-inflammatory cytokine release from lung epithelial cells

N. M. Smith, P. Soh, N. Asokananthan, M. Norret, G. A. Stewart and C. L. Raston, New J. Chem., 2009, 33, 1869 DOI: 10.1039/B909172F

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