Issue 9, 2009
From the journal:

New Journal of Chemistry

A selective fluorescent sensor for imaging Cu2+ in living cells

Lijuan Jiao,*ab   Jilong Li,ab   Shengzhou Zhang,c   Chao Wei,c   Erhong Haoab  and  M. Graça H. Vicented  

* Corresponding authors

a Anhui Key Laboratory of Functional Molecular Solids, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui, P.R. China
E-mail: jiao421@mail.ahnu.edu.cn
Fax: +86-553-3869303
Tel: +86-553-3869303

b Anhui Key Laboratory of Molecular-Based Materials, Anhui Normal University, Wuhu, Anhui, P.R. China

c College of Life Science, Anhui Normal University, Wuhu, Anhui, P.R. China

d Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA
E-mail: vicente@lsu.edu
Fax: 225-578-3458
Tel: 225-578-7405

Abstract

Copper ion is a biochemically essential yet toxic metal ion, connected to serious neurodegenerative diseases, and also has been identified as an environmental pollutant. For the effective detection of Cu2+ in biological and environmental systems, we have developed a new membrane-permeable Cu2+-selective water-soluble BODIPY 1, which was synthesized by nucleophilic disubstitution of novel 3,5-diiodo-BODIPY 4 with N,N-bis(2-hydroxyethyl)amines. BODIPY 1 shows a highly sensitive and selective fluorescence response to Cu2+ in aqueous solution. Fluorescence image experiments establish that 1 can be used to monitor intracellular Cu2+ within living cells.

Graphical abstract: A selective fluorescent sensor for imaging Cu2+ in living cells

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Article information

DOI
https://doi.org/10.1039/B906441A
Article type
Paper
Submitted
01 Apr 2009
Accepted
08 May 2009
First published
16 Jun 2009

New J. Chem., 2009,33, 1888-1893

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A selective fluorescent sensor for imaging Cu2+ in living cells

L. Jiao, J. Li, S. Zhang, C. Wei, E. Hao and M. G. H. Vicente, New J. Chem., 2009, 33, 1888 DOI: 10.1039/B906441A

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