Issue 9, 2009

Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

Abstract

From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones were shown to be isoform-selective PKC-ζ inhibitors.

Graphical abstract: Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

Supplementary files

Article information

Article type
Communication
Submitted
18 Feb 2009
Accepted
08 Apr 2009
First published
08 May 2009

Mol. BioSyst., 2009,5, 927-930

Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

L. Yuan, J. Seo, N. S. Kang, S. Keinan, S. E. Steele, G. A. Michelotti, W. C. Wetsel, D. N. Beratan, Y. Gong, T. H. Lee and J. Hong, Mol. BioSyst., 2009, 5, 927 DOI: 10.1039/B903036K

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