A photostable fluorescent probe for targeted imaging of tumour cells possessing integrin αvβ3**

Liqin Xiong; Mengxiao Yu; Mingjun Cheng; Meng Zhang; Xiaoyan Zhang; Congjian Xu; Fuyou Li

doi:10.1039/B820576K

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A photostable fluorescent probe for targeted imaging of tumour cells possessing integrin α_vβ₃**†

Liqin Xiong,^a Mengxiao Yu,^a Mingjun Cheng,^b Meng Zhang,^a Xiaoyan Zhang,^b Congjian Xu*^b and Fuyou Li*^a

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* Corresponding authors

^a Department of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai, P. R. China
E-mail: fyli@fudan.edu.cn
Fax: +86-21-55664621
Tel: +86-21-55664185

^b The Obstetrics and Gynecology Hospital, Fudan University, Shanghai, P. R. China
E-mail: xucj@hotmail.com

Abstract

A one-step S_NAr^H reaction has been used for the synthesis of photostable probe 2, which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin α_vβ₃ and an arginine–glycine–aspartic acid tripeptide sequence.

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Article information

DOI: https://doi.org/10.1039/B820576K
Article type: Communication
Submitted: 17 Nov 2008
Accepted: 16 Dec 2008
First published: 07 Jan 2009

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Mol. BioSyst., 2009,5, 241-243

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A photostable fluorescent probe for targeted imaging of tumour cells possessing integrin α_vβ₃**

L. Xiong, M. Yu, M. Cheng, M. Zhang, X. Zhang, C. Xu and F. Li, Mol. BioSyst., 2009, 5, 241 DOI: 10.1039/B820576K

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Molecular BioSystems