Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

Jonathan Swann; Yulan Wang; Leticia Abecia; Adele Costabile; Kieran Tuohy; Glenn Gibson; David Roberts; James Sidaway; Huw Jones; Ian D. Wilson; Jeremy Nicholson; Elaine Holmes

doi:10.1039/B811468D

Gut microbiome modulates the toxicity of hydrazine: a metabonomic study†

Jonathan Swann,^a Yulan Wang,^a Leticia Abecia,^b Adele Costabile,^b Kieran Tuohy,^b Glenn Gibson,^b David Roberts,^c James Sidaway,^d Huw Jones,^d Ian D. Wilson,^c Jeremy Nicholson^a and Elaine Holmes*^a

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^a Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus, London, UK
E-mail: elaine.holmes@imperial.ac.uk

^b Department of Food Biosciences, The School of Chemistry, Food Biosciences and Pharmacy, The University of Reading, Whiteknights, Reading, UK

^c Department of Clinical Pharmacology, Drug Metabolism and Pharmacokinetics, AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK

^d Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK

Abstract

The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and ‘conventional’ Sprague Dawley rats using ¹H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.

Molecular BioSystems

Gut microbiome modulates the toxicity of hydrazine: a metabonomic study†

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Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

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