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Issue 17, 2009
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Microchemical systems for continuous-flow synthesis

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Microchemical systems have evolved rapidly over the last decade with extensive chemistry applications. Such systems enable discovery and development of synthetic routes while simultaneously providing increased understanding of underlying pathways and kinetics. We review basic trends and aspects of microsystems as they relate to continuous-flow microchemical synthesis. Key literature reviews are summarized and principles governing different microchemical operations discussed. Current trends and limitations of microfabrication, micromixing, chemical synthesis in microreactors, continuous-flow separations, multi-step synthesis, and integration of analytics are delineated. We conclude by summarizing the major challenges and outlook related to these topics.

Graphical abstract: Microchemical systems for continuous-flow synthesis

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The article was received on 31 Mar 2009, accepted on 01 May 2009 and first published on 28 May 2009

Article type: Critical Review
DOI: 10.1039/B906343A
Lab Chip, 2009,9, 2495-2507

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    Microchemical systems for continuous-flow synthesis

    R. L. Hartman and K. F. Jensen, Lab Chip, 2009, 9, 2495
    DOI: 10.1039/B906343A

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