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Issue 10, 2009
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Reliable microfluidic on-chip incubation of droplets in delay-lines

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Abstract

Together with droplet creation, fusion and sorting, the incubation of droplets is one of the most important and essential operations for droplet-based microfluidic assays. This manuscript concerns the development of delay-lines, which are necessary to allow incubation of reactions for precise time periods. We analyze the problems associated with creating delay-lines for incubation in the minute to hour time range, which arise from back-pressure and from the dispersion in the incubation time due to the unequal speeds with which droplets pass through the delay-line. We describe delay-line systems which resolve these problems and demonstrate their use to measure reaction kinetics over several minutes in droplets.

Graphical abstract: Reliable microfluidic on-chip incubation of droplets in delay-lines

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Publication details

The article was received on 15 Sep 2008, accepted on 24 Nov 2008 and first published on 19 Dec 2008


Article type: Paper
DOI: 10.1039/B816049J
Citation: Lab Chip, 2009,9, 1344-1348
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    Reliable microfluidic on-chip incubation of droplets in delay-lines

    L. Frenz, K. Blank, E. Brouzes and A. D. Griffiths, Lab Chip, 2009, 9, 1344
    DOI: 10.1039/B816049J

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