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Issue 3, 2009
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Two-dimensional droplet-based surface plasmon resonance imaging using electrowetting-on-dielectric microfluidics

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Abstract

This article presents a multichannel droplet-based surface plasmon resonance platform. The platform comprises a digital electrowetting-on-dielectric (EWOD) microfluidic device coupled to surface plasmon resonance imaging (SPRi). SPRi is now a well-established detection technique that enables in-situ monitoring of multiple reactions occurring at the surface of the chip without the use of labels. Currently, the limiting factor in the application of SPRi for high-throughput applications is the flow-cell technology which relies on sequential sample processing within the continuous fluid flow. An original solution compared to the continuous flow-cell technology is proposed to increase the capability of existing SPRi technology. A parallel SPRi detection of different samples on the surface is achieved using the array-based digital microfluidic device.

Graphical abstract: Two-dimensional droplet-based surface plasmon resonance imaging using electrowetting-on-dielectric microfluidics

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Publication details

The article was received on 27 Aug 2008, accepted on 14 Oct 2008 and first published on 07 Nov 2008


Article type: Technical Note
DOI: 10.1039/B814697G
Lab Chip, 2009,9, 473-475

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    Two-dimensional droplet-based surface plasmon resonance imaging using electrowetting-on-dielectric microfluidics

    L. Malic, T. Veres and M. Tabrizian, Lab Chip, 2009, 9, 473
    DOI: 10.1039/B814697G

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