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Issue 44, 2009
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Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals

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Abstract

This study widens the role of biomimetic hydroxyapatite (HA) nanocrystals as bone substitutes and describes how they can be used as bone-specific drug delivery devices for in situ treatment of bone tumors upon local implantation. The adsorption and release kinetics of bis-{ethylenediamineplatinum(II)}-2-amino-1-hydroxyethane-1,1-diyl-bisphosphonate and bis-{ethylenediamineplatinum(II)}medronate on two kinds of HA nanocrystals having different morphologies, crystallinity degrees and surface areas have been investigated. The different chemical structures of the two Pt complexes appreciably affect not only the affinity towards the two kinds of HA, but also their release. The Pt complex loading is slightly greater for the HA characterized by lower crystallinity and higher surface area, with respect to the more crystalline one. The cytotoxicity of Pt complexes released from the HA were tested against human cervix carcinoma cells and, interestingly, were found to be more cytotoxic than the unmodified complexes. The released Pt species are therefore the active dichloridoethylenediamineplatinum(II) or related solvato species formed by Pt-bisphosphonate bond breaking.

Graphical abstract: Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals

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Article information


Submitted
17 Jul 2009
Accepted
28 Aug 2009
First published
23 Sep 2009

J. Mater. Chem., 2009,19, 8385-8392
Article type
Paper

Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals

M. Iafisco, B. Palazzo, M. Marchetti, N. Margiotta, R. Ostuni, G. Natile, M. Morpurgo, V. Gandin, C. Marzano and N. Roveri, J. Mater. Chem., 2009, 19, 8385
DOI: 10.1039/B914379C

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