In vivo multiple color lymphatic imaging using upconverting nanocrystals

Hisataka Kobayashi; Nobuyuki Kosaka; Mikako Ogawa; Nicole Y. Morgan; Paul D. Smith; Christopher B. Murray; Xingchen Ye; Josh Collins; G. Ajith Kumar; Howard Bell; Peter L. Choyke

doi:10.1039/B910512C

In vivo multiple color lymphatic imaging using upconverting nanocrystals†

Hisataka Kobayashi,*^a Nobuyuki Kosaka,^a Mikako Ogawa,^a Nicole Y. Morgan,^b Paul D. Smith,^b Christopher B. Murray,^c Xingchen Ye,^c Josh Collins,^c G. Ajith Kumar,^d Howard Bell^d and Peter L. Choyke^a

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* Corresponding authors

^a Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bldg. 10, Room 1B40, MSC 1088, Bethesda, MD 20892-1088, USA
E-mail: Kobayash@mail.nih.gov

^b National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD 20892, USA

^c University of Pennsylvania, Philadelphia, PA 19104, USA

^d Sunstone BioSciences, Inc., Philadelphia, PA 19104, USA

Abstract

Upconverting nanocrystals are unique nano-sized particles that emit light at shorter wavelengths (visible and near infrared) after excitation in the near infrared that dramatically reduces background autofluorescence in in vivo two color lymphatic imaging for depicting the lymphatic channels and nodes.

Journal of Materials Chemistry

In vivo multiple color lymphatic imaging using upconverting nanocrystals†

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In vivo multiple color lymphatic imaging using upconverting nanocrystals

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