Issue 9, 2009
From the journal:

Green Chemistry

Catalyst-free aldol condensation of ketones and isatins under mild reaction conditions in DMF with molecular sieves 4 Å as additive†

Wen-Bing Chen,ab   Yu-Hua Liao,ab   Xi-Lin Du,c   Xiao-Mei Zhanga  and  Wei-Cheng Yuan*a  

* Corresponding authors

a Key Laboratory for Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, P. R. of China
E-mail: yuanwc@cioc.ac.cn
Fax: +86 (28) 85229250

b Graduate School of Chinese Academy of Sciences, Beijing, P. R. of China

c Department of General Surgery, TangDu Hospital, The Fourth Military Medical University, Xi'an, P. R. of China

Abstract

In the presence of molecular sieve (MS) 4 Å in DMF, a catalyst-free aldol condensation of a variety of aromatic and aliphatic ketones with isatins under mild reaction conditions has been developed. This approach may provide access to a wide range of 3-substituted-3-hydroxyindolin-2-ones in good to excellent yields.

Graphical abstract: Catalyst-free aldol condensation of ketones and isatins under mild reaction conditions in DMF with molecular sieves 4 Å as additive

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Article information

DOI
https://doi.org/10.1039/B906684E
Article type
Paper
Submitted
03 Apr 2009
Accepted
19 Jun 2009
First published
14 Jul 2009

Green Chem., 2009,11, 1465-1476

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Catalyst-free aldol condensation of ketones and isatins under mild reaction conditions in DMF with molecular sieves 4 Å as additive

W. Chen, Y. Liao, X. Du, X. Zhang and W. Yuan, Green Chem., 2009, 11, 1465 DOI: 10.1039/B906684E

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