Issue 5, 2009
From the journal:

Green Chemistry

Combined action of enzymes: the first domino reaction catalyzed by Agaricus bisporus

Heiko Leutbecher,a   Szilvia Hajdok,a   Christina Braunberger,a   Melanie Neumann,a   Sabine Mika,a   Jürgen Conrada  and  Uwe Beifuss*a  

* Corresponding authors

a Bioorganische Chemie, Institut für Chemie, Universität Hohenheim, Garbenstr. 30, Stuttgart, Germany
E-mail: ubeifuss@uni-hohenheim.de
Fax: (+49) 711 459 22951
Tel: (+ 49) 711 459 22171

Abstract

The enzymes tyrosinase and laccase from a crude extract of the button mushroom (Agaricus bisporus) can be employed to catalyze the domino reaction between phenol and various cyclic 1,3-dicarbonyls using atmospheric oxygen as the oxidizing agent and yielding annulated benzofuranes in a highly efficient and sustainable manner.

Graphical abstract: Combined action of enzymes: the first domino reaction catalyzed by Agaricus bisporus

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Article information

DOI
https://doi.org/10.1039/B822977E
Article type
Communication
Submitted
24 Dec 2008
Accepted
18 Feb 2009
First published
27 Feb 2009

Green Chem., 2009,11, 676-679

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Combined action of enzymes: the first domino reaction catalyzed by Agaricus bisporus

H. Leutbecher, S. Hajdok, C. Braunberger, M. Neumann, S. Mika, J. Conrad and U. Beifuss, Green Chem., 2009, 11, 676 DOI: 10.1039/B822977E

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