Jump to main content
Jump to site search

Issue 44, 2009
Previous Article Next Article

Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, 57Fe Mössbauer, and biological activity studies

Author affiliations

Abstract

The iron(III) salen-type complexes [Fe(salen)(L)]n (1–6) involving heterocyclic N-donor ligands HL {HL = 1H-imidazole (Himz), 1H-tetrazol-5-amine (Hatz), 5-methyl-1H-tetrazole (Hmtz), 1H-benzimidazole (Hbimz), 1H-1,2,4-triazole (Htriz) and 1H-benzotriazole (Hbtriz)} have been prepared and characterised by elemental analysis, FT IR, CI mass and 57Fe Mössbauer spectroscopies, and variable temperature magnetic measurements. Single crystal X-ray analysis of [Fe(salen)(btriz)]n (6) revealed a 1D chain-polymeric structure of the complex with the btriz anion as a bridging ligand. Magnetic data for all complexes were fitted using Fisher's model (for S = 5/2) and also using a heptanuclear closed ring model showing a weak antiferromagnetic interaction (J≈−1 to −2 cm−1), and moreover, molecule-based magnet properties have been observed in the case of [Fe(salen)(atz)]n (2). The exponential correlation between the magnetic properties (the isotropic exchange parameter J) and the basicity of the free ligands (Kb) has been found. The antiferromagnetic ordering as well as a moderate structural dissimilarity in the vicinity of iron atoms has been proved by the 57Fe Mössbauer low-temperature (2 K) in-field (7 T) experiments in the case of (2), in which two sextets with the line intensities (3/4/1/3/4/1) have been observed. The compounds have been tested for their SOD-like activity, DNA cleavage activity, and in vitro cytotoxicity against two human cancer cell lines: chronic myelogenous erythroleukemia (K562) and breast adenocarcinoma (MCF7). The best result regarding the cytotoxicity has been achieved for the complex of [Fe(salen)(atz)]n (2), where IC50 = 6.4 μM against K562.

Graphical abstract: Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, 57Fe Mössbauer, and biological activity studies

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Jun 2009, accepted on 10 Sep 2009 and first published on 02 Oct 2009


Article type: Paper
DOI: 10.1039/B912676G
Citation: Dalton Trans., 2009,0, 9870-9880
  •   Request permissions

    Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, 57Fe Mössbauer, and biological activity studies

    R. Herchel, Z. Šindelář, Z. Trávníček, R. Zbořil and J. Vančo, Dalton Trans., 2009, 0, 9870
    DOI: 10.1039/B912676G

Search articles by author

Spotlight

Advertisements