Issue 48, 2009
From the journal:

Dalton Transactions

Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes

Esther Schuh,a   Seied M. Valiahdi,b   Michael A. Jakupec,b   Bernhard K. Keppler,b   Peter Chibac  and  Fabian Mohr*a  

* Corresponding authors

a Fachbereich C, Anorganische Chemie Bergische Universität Wuppertal, Gaußstr. 20, Wuppertal, Germany
E-mail: fmohr@uni-wuppertal.de
Fax: +49 202 439 3053
Tel: +49 202 439 3641

b Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria

c Institute of Medical Chemistry, Medical University of Vienna, Vienna, Austria

Abstract

The propargyl ethers 7-chloro-(4-propargyloxy)quinoline, 1-propargyloxynaphthalene and 2-propargyloxybenzophenone react with [AuCl(PPh3)] in the presence of KOH to give the gold(I) alkynyl complexes [Au(C[triple bond, length as m-dash]COCH2Ar)(PPh3)] in good yields. The compounds were fully characterised by spectroscopic methods and were subsequently examined for their biological activity against four tumour cell lines as well as their activity against Plasmodium falciparum, the parasite responsible for malaria. The compounds show antiproliferative effects in human cancer cells with IC50 values ranging from 0.4–12 μM.

Graphical abstract: Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes

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Article information

DOI
https://doi.org/10.1039/B911234K
Article type
Paper
Submitted
10 Jun 2009
Accepted
17 Sep 2009
First published
08 Oct 2009

Dalton Trans., 2009, 10841-10845

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Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes

E. Schuh, S. M. Valiahdi, M. A. Jakupec, B. K. Keppler, P. Chiba and F. Mohr, Dalton Trans., 2009, 10841 DOI: 10.1039/B911234K

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