Jump to main content
Jump to site search

Issue 38, 2009
Previous Article Next Article

The metal-binding sites of glycose phosphates

Author affiliations


In aqueous solution, the reducing sugar phosphates D-arabinose 5-phosphate, D-ribose 5-phosphate, D-fructose 1,6-bisphosphate, D-fructose 6-phosphate, D-glucose 6-phosphate and D-mannose 6-phosphate provide metal-binding sites at their glycose core on reaction with PdII(en) or MIII(tacn) residues (M = Ga, Co; en = ethylenediamine, tacn = 1,4,7-triazacyclononane). The individual species were detected by one- and two-dimensional NMR spectroscopy. The coordination patterns are related to the metal-binding modes of the respective parent glycoses. In detail, ribo- and arabinofuranose phosphate favour κO1,3 coordination, whereas the ketofuranose core of fructose phosphate and fructose bisphosphate provides the κO2,3 chelator thus maintaining the configuration of the respective major solution anomer. On palladium excess, D-fructose 6-phosphate is metallated twice in a unique κO1,3 : κO2,4 metallation pattern. Dimetallation is also found for the aldohexose phosphates. A mixed glycose-core–phosphate chelation was detected for PdII(en) and MIII(tacn) residues with M = Al, Ga in the pH range just above the physiological pH for the D-fructose 1,6-bisphosphate ligand. The results are discussed in relation to D-fructose-1,6-bisphosphate-metabolism in class-II aldolases.

Graphical abstract: The metal-binding sites of glycose phosphates

Back to tab navigation

Supplementary files

Article information

12 May 2009
23 Jun 2009
First published
31 Jul 2009

Dalton Trans., 2009, 7934-7945
Article type

The metal-binding sites of glycose phosphates

K. Gilg, T. Mayer, N. Ghaschghaie and P. Klüfers, Dalton Trans., 2009, 7934
DOI: 10.1039/B909431H

Social activity

Search articles by author