Catalytic (transfer) deuterogenation in D2O as deuterium source with H2 and HCO2H as electron sources

Abstract

Deuterium-labelled compounds were prepared by (transfer) deuterogenation of unsaturated compounds using H₂ or HCO₂H in acidic D₂O as deuterium source with almost quantitative yields and high deuterium contents under mild reaction conditions via heterolytic cleavage of H₂ (or decomposition of HCO₂H) and rapid H⁺/D⁺ exchange using iridium catalysts with 4,4′-dihydroxy-2,2′-bipyridine.