Apoptosis and anti-tumour activities of manganese(iii)-salen and -salphen complexes
Abstract
We analyzed the apoptosis and anti-tumour activities of several MnIII-salen and -salphen complexes (1–14) towards three different cultured human cancer and non-cancer cells. We demonstrated that most of the MnIII-salen and -salphen complexes affect cell viability and induce apoptosis in MCF7 cells. Biochemically active MnIII-salen and -salphen complexes induced nuclear fragmentation and release of