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Issue 25, 2009
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The structural effects of the Cys-S-S-Cys bridge exchange by the His-Cu(II)-His motif studied on natural peptides — a promising tool for natural compounds-based design

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Abstract

A replacement of both Cys residues by His in oxytocin (OXT) sequence allows for the formation of the stable complex with the {NH2, NIm, NIm(macrochelate)} binding mode at the physiological pH. The detailed potentiometric and spectroscopic studies on the Cu(II) complexes of [His1,6]OXT, together with high resolution NMR investigations on 3D structures of Cu(II) complexes with [His1,6]OXT and [His1,6]AVP analogues are presented and discussed. Exchange of the Cys-S-S-Cys bridge by the His-Cu(II)-His motif is very promising, because the resulting complexes retain topological similarity to the native S–S bridged AVP and OXT at pH values corresponding to the physiological pH.

Graphical abstract: The structural effects of the Cys-S-S-Cys bridge exchange by the His-Cu(II)-His motif studied on natural peptides — a promising tool for natural compounds-based design

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Publication details

The article was received on 26 Jan 2009, accepted on 23 Apr 2009 and first published on 12 May 2009


Article type: Communication
DOI: 10.1039/B901676G
Dalton Trans., 2009, 4853-4857

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    The structural effects of the Cys-S-S-Cys bridge exchange by the His-Cu(II)-His motif studied on natural peptides — a promising tool for natural compounds-based design

    J. Brasuń, M. Cebrat, Ł. Jaremko, M. Jaremko, G. Ilc, O. Gładysz and I. Zhukov, Dalton Trans., 2009, 4853
    DOI: 10.1039/B901676G

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