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Issue 8, 2009
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Nanopore analytics: sensing of single molecules

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Abstract

In nanopore analytics, individual molecules pass through a single nanopore giving rise to detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore analytics has gained popularity and can be conducted with natural protein as well as man-made polymeric and inorganic pores. The spectrum of detectable analytes ranges from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Apart from being an analytical tool, nanopores have developed into a general platform technology to investigate the biophysics, physicochemistry, and chemistry of individual molecules (critical review, 310 references).

Graphical abstract: Nanopore analytics: sensing of single molecules

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Publication details

The article was received on 17 Feb 2009 and first published on 15 Jun 2009


Article type: Critical Review
DOI: 10.1039/B813796J
Citation: Chem. Soc. Rev., 2009,38, 2360-2384

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    Nanopore analytics: sensing of single molecules

    S. Howorka and Z. Siwy, Chem. Soc. Rev., 2009, 38, 2360
    DOI: 10.1039/B813796J

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