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Issue 9, 2009
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Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

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Abstract

The first example of a trimorphic cocrystal involving two active pharmaceutical ingredients (APIs), ethenzamide and gentisic acid, is reported; metastable polymorphs convert to the stable form upon solid-state grinding; pharmaceutical cocrystals involving two or more APIs have potential relevance to combination drugs.

Graphical abstract: Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

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Publication details

The article was received on 05 Mar 2009, accepted on 29 May 2009 and first published on 19 Jun 2009


Article type: Communication
DOI: 10.1039/B904616J
Citation: CrystEngComm, 2009,11, 1823-1827

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    Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

    S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823
    DOI: 10.1039/B904616J

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