Issue 39, 2009
From the journal:

Chemical Communications

Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein†

Ignacio Pérez-Victoria,‡a   Sebastian Kemper,‡a   Mitul K. Patel,a   John M. Edwards,a   James C. Errey,a   Lucia F. Primavesi,b   Matthew J. Paul,b   Timothy D. W. Claridge*a  and  Benjamin G. Davis*a  

* Corresponding authors

a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK
E-mail: Tim.Claridge@chem.ox.ac.uk, Ben.Davis@chem.ox.ac.uk
Fax: +44 (0)1865 285002
Tel: +44 (0)1865 285001

b Plant Science, Rothamsted Research, Harpenden, Herts, UK

Abstract

The binding kinetics of disaccharides trehalose and trehalose-6-phosphate to repressor protein TreR have been determined using STD NMR and shed light on the contrasting biological roles of these two sugars.

Graphical abstract: Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein

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Article information

DOI
https://doi.org/10.1039/B913489A
Article type
Communication
Submitted
07 Jul 2009
Accepted
03 Aug 2009
First published
19 Aug 2009

Chem. Commun., 2009, 5862-5864

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Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein

I. Pérez-Victoria, S. Kemper, M. K. Patel, J. M. Edwards, J. C. Errey, L. F. Primavesi, M. J. Paul, T. D. W. Claridge and B. G. Davis, Chem. Commun., 2009, 5862 DOI: 10.1039/B913489A

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