Issue 39, 2009

The synthesis of allenes by Cu(i)-catalyzed regio- and stereoselective reduction of propargylic carbonates with hydrosilanes

Abstract

Cu(I)-catalyzed anti-SN2′-type reduction of internal propargylic carbonates with hydrosilanes affords various di- and trisubstituted allenes with high regioselectivities; the reactions are compatible with functional groups and work efficiently for the synthesis of optically-active allenes.

Graphical abstract: The synthesis of allenes by Cu(i)-catalyzed regio- and stereoselective reduction of propargylic carbonates with hydrosilanes

Supplementary files

Article information

Article type
Communication
Submitted
26 May 2009
Accepted
23 Jul 2009
First published
11 Aug 2009

Chem. Commun., 2009, 5850-5852

The synthesis of allenes by Cu(I)-catalyzed regio- and stereoselective reduction of propargylic carbonates with hydrosilanes

C. Zhong, Y. Sasaki, H. Ito and M. Sawamura, Chem. Commun., 2009, 5850 DOI: 10.1039/B910192F

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