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Issue 31, 2009
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Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable

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Abstract

The anti-AIDS drug AZT was covalently attached to the recently reported sorbitol-G8 transporter, and the conjugate was found to target mitochondria in HeLa cells and readily cross the blood–brain barrier (BBB) to gain access into the mouse brain, suggesting the potential of these molecular transporters as practical central nervous system (CNS) delivery vectors.

Graphical abstract: Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable

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The article was received on 13 May 2009, accepted on 04 Jun 2009 and first published on 22 Jun 2009


Article type: Communication
DOI: 10.1039/B909541A
Citation: Chem. Commun., 2009,0, 4669-4671
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    Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable

    J. Im, W. Kim, K. Kim and S. Chung, Chem. Commun., 2009, 0, 4669
    DOI: 10.1039/B909541A

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