A new C–C bond forming annulation reaction leading to pH switchable heterocycles†
Abstract
A C–C bond forming reaction resulting from the α-addition of carbon based nucleophiles to N-bromoethyl phenanthridinium leads to the formation of 2,3-dihydro-12H-pyrrolo[1,2-f]phenanthridine-based derivatives which undergo reversible ring-opening/closing under pH control.