Issue 16, 2009

Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling

Abstract

An efficient and convenient Negishi coupling protocol was developed for the preparation of 3-aryl-2,2-dimethylpropanoates providing easy access to key pharmaceutical intermediates that often require multi-step synthesis using conventional enolate chemistry.

Graphical abstract: Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling

Supplementary files

Article information

Article type
Communication
Submitted
10 Feb 2009
Accepted
05 Mar 2009
First published
23 Mar 2009

Chem. Commun., 2009, 2145-2147

Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling

Y. Kwak, A. D. Kanter, B. Wang and Y. Liu, Chem. Commun., 2009, 2145 DOI: 10.1039/B902779C

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