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Issue 16, 2009
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Combining two-directional synthesis and tandem reactions: new access to 3,5-disubstituted pyrrolizidines and first total synthesis of alkaloidcis-223B

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Abstract

Two new tandem reactions for the synthesis of 3,5-disubstituted pyrrolizidines and the first total synthesis of alkaloidcis-223B (in 7 steps and 43% overall yield), involving a double cross metathesis and double Michael addition as key steps, are presented.

Graphical abstract: Combining two-directional synthesis and tandem reactions: new access to 3,5-disubstituted pyrrolizidines and first total synthesis of alkaloidcis-223B

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Publication details

The article was received on 09 Jan 2009, accepted on 28 Jan 2009 and first published on 03 Mar 2009


Article type: Communication
DOI: 10.1039/B900451C
Citation: Chem. Commun., 2009,0, 2207-2209

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    Combining two-directional synthesis and tandem reactions: new access to 3,5-disubstituted pyrrolizidines and first total synthesis of alkaloidcis-223B

    J. Legeay, W. Lewis and R. A. Stockman, Chem. Commun., 2009, 0, 2207
    DOI: 10.1039/B900451C

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