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Issue 48, 2009
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Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

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Abstract

A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-subtrates under room temperature or mild conditions.

Graphical abstract: Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

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Article information


Submitted
07 Sep 2009
Accepted
16 Oct 2009
First published
04 Nov 2009

Chem. Commun., 2009, 7581-7583
Article type
Communication

Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

Q. Cai, Z. Li, J. Wei, C. Ha, D. Pei and K. Ding, Chem. Commun., 2009, 7581
DOI: 10.1039/B918345K

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