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Issue 44, 2009
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Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct α-cyanoamination of ketones and aldehydes

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Abstract

The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary amine, acetyl cyanide as the cyanide source and N,N-dimethylcyclohexylamine as the catalyst.

Graphical abstract: Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct α-cyanoamination of ketones and aldehydes

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Publication details

The article was received on 22 Jul 2009, accepted on 14 Sep 2009 and first published on 29 Sep 2009


Article type: Communication
DOI: 10.1039/B914151K
Chem. Commun., 2009, 6839-6841

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    Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct α-cyanoamination of ketones and aldehydes

    F. Cruz-Acosta, A. Santos-Expósito, P. de Armas and F. García-Tellado, Chem. Commun., 2009, 6839
    DOI: 10.1039/B914151K

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