Issue 46, 2009
From the journal:

Chemical Communications

Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-proteinblock copolymers†

Han-Nah Kim,‡a   Jin Lee,‡a   Hae-Yeong Kima  and  Young-Rok Kim*a  

* Corresponding authors

a Institute of Life Sciences and Resources & Department of Food Science and Biotechnology, Kyung Hee University, Yongin 446-701, Korea
E-mail: youngkim@khu.ac.kr
Fax: +82 31 204-8116
Tel: +82 31 201 3830

Abstract

A new approach to prepare functional polymeric micelles in a one step reaction using the unique catalytic property of PHA synthase is described. A biopolymer-based nanocarrier with cancer targeting capability was successfully synthesized from genetically engineered PHA synthase fused with RGDpeptide.

Graphical abstract: Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-proteinblock copolymers

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Article information

DOI
https://doi.org/10.1039/B912871A
Article type
Communication
Submitted
30 Jun 2009
Accepted
26 Aug 2009
First published
09 Sep 2009

Chem. Commun., 2009, 7104-7106

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Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-proteinblock copolymers

H. Kim, J. Lee, H. Kim and Y. Kim, Chem. Commun., 2009, 7104 DOI: 10.1039/B912871A

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