Issue 42, 2009
From the journal:

Chemical Communications

Gd(DO3A-N-α-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents†

Miguel F. Ferreira,a   André F. Martins,b   José A. Martins,*a   Paula M. Ferreira,a   Éva Tóth*c  and  Carlos F.G.C. Geraldes*b  

* Corresponding authors

a Centro de Química, Campus de Gualtar, Universidade do Minho, Portugal
E-mail: jmartins@quimica.uminho.pt
Fax: +351253604382
Tel: +351253604385

b Department of Biochemistry, NMR Center and Center of Neurosciences and Cell Biology, Faculty of Science and Technology, University of Coimbra, P.O. Box 3126, 3001-401 Coimbra, Portugal
E-mail: geraldes@bioq.uc.pt
Fax: +351239853608
Tel: +351239853607

c Centre de Biophysique Moléculaire, CNRS, Rue Charles Sadron, 45071 Orléans, France
E-mail: eva.jakabtoth@cnrs-orleans.fr
Fax: +33238257625
Tel: +33238631517

Abstract

We report the synthesis of a novel, versatile and easily accessible metal chelator, DO3A-N-α-aminopropionate, and the relaxometric characterization of its Gd3+ complex, revealing great potential for the development of high relaxivity targeted contrast agents for magnetic resonance imaging.

Graphical abstract: Gd(DO3A-N-α-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

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Article information

DOI
https://doi.org/10.1039/B912201J
Article type
Communication
Submitted
22 Jun 2009
Accepted
14 Aug 2009
First published
09 Sep 2009

Chem. Commun., 2009, 6475-6477

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Gd(DO3A-N-α-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

M. F. Ferreira, A. F. Martins, J. A. Martins, P. M. Ferreira, É. Tóth and C. F.G.C. Geraldes, Chem. Commun., 2009, 6475 DOI: 10.1039/B912201J

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