Issue 43, 2009
From the journal:

Chemical Communications

Site-selective scission of human genome by artificial restriction DNA cutter†

Kenichiro Ito,a   Hitoshi Katada,a   Narumi Shigi*a  and  Makoto Komiyama*a  

* Corresponding authors

a Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, 153-8904 Tokyo, Japan
E-mail: narumi@mkomi.rcast.u-tokyo.ac.jp; komiyama@mkomi.rcast.u-tokyo.ac.jp
Fax: +81-3-452-5209
Tel: +81-3-5452-5200

Abstract

By using an artificial restriction DNA cutter which is composed of Ce(IV)/EDTA and two pseudo-complementary peptide nucleic acid strands (pcPNAs), only one target site in the whole genome of human beings (one site in the X chromosome) was selectively hydrolyzed.

Graphical abstract: Site-selective scission of human genome by artificial restriction DNA cutter

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Article information

DOI
https://doi.org/10.1039/B911208A
Article type
Communication
Submitted
09 Jun 2009
Accepted
22 Aug 2009
First published
08 Sep 2009

Chem. Commun., 2009, 6542-6544

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Site-selective scission of human genome by artificial restriction DNA cutter

K. Ito, H. Katada, N. Shigi and M. Komiyama, Chem. Commun., 2009, 6542 DOI: 10.1039/B911208A

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