Issue 42, 2009
From the journal:

Chemical Communications

Hydrolysis of phosphohistidine in water and in prostatic acid phosphatase†

Satyan Sharmaa  and  André H. Juffer*a  

* Corresponding authors

a Biocenter Oulu and the Department of Biochemistry, PL 3000, University of Oulu, Finland
E-mail: andre.juffer@oulu.fi
Fax: +358-8-553-1141
Tel: +358-8-553-1161

Abstract

Calculation of the free energy profile for hydrolysis of phosphohistidine using ONIOM methodology indicates a much tighter transition state in the enzyme active site compared to that in explicit water and elucidates the role of active site residues in catalysis.

Graphical abstract: Hydrolysis of phosphohistidine in water and in prostatic acid phosphatase

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Article information

DOI
https://doi.org/10.1039/B910451H
Article type
Communication
Submitted
28 May 2009
Accepted
10 Sep 2009
First published
25 Sep 2009

Chem. Commun., 2009, 6385-6387

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Hydrolysis of phosphohistidine in water and in prostatic acid phosphatase

S. Sharma and A. H. Juffer, Chem. Commun., 2009, 6385 DOI: 10.1039/B910451H

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