Issue 31, 2009

Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable

Abstract

The anti-AIDS drug AZT was covalently attached to the recently reported sorbitol-G8 transporter, and the conjugate was found to target mitochondria in HeLa cells and readily cross the blood–brain barrier (BBB) to gain access into the mouse brain, suggesting the potential of these molecular transporters as practical central nervous system (CNS) delivery vectors.

Graphical abstract: Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
13 May 2009
Accepted
04 Jun 2009
First published
22 Jun 2009

Chem. Commun., 2009, 4669-4671

Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable

J. Im, W. Kim, K. Kim and S. Chung, Chem. Commun., 2009, 4669 DOI: 10.1039/B909541A

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