Issue 31, 2009
From the journal:

Chemical Communications

Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable†

Jungkyun Im,a   Wanil Kim,b   Kyong-Tai Kimb  and  Sung-Kee Chung*a  

* Corresponding authors

a Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
E-mail: skchung@postech.ac.kr
Fax: (+82)54-279-3399
Tel: (+82)54-279-2764

b Department of Life Science, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea

Abstract

The anti-AIDS drug AZT was covalently attached to the recently reported sorbitol-G8 transporter, and the conjugate was found to target mitochondria in HeLa cells and readily cross the blood–brain barrier (BBB) to gain access into the mouse brain, suggesting the potential of these molecular transporters as practical central nervous system (CNS) delivery vectors.

Graphical abstract: Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable

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Article information

DOI
https://doi.org/10.1039/B909541A
Article type
Communication
Submitted
13 May 2009
Accepted
04 Jun 2009
First published
22 Jun 2009

Chem. Commun., 2009, 4669-4671

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Preparation of a 3′-azido-3′-deoxythymidine (AZT) derivative, which is blood–brain barrier permeable

J. Im, W. Kim, K. Kim and S. Chung, Chem. Commun., 2009, 4669 DOI: 10.1039/B909541A

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