Issue 28, 2009

Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptidetoxins using olefin metathesis

Abstract

Bis-dicarba analogues of native dicystine-containing α-conotoxin Rg1A, an analgesic peptide isolated from cone snail venom, were constructed on resin using a regioselective metathesis–hydrogenation strategy.

Graphical abstract: Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis

Supplementary files

Article information

Article type
Communication
Submitted
07 May 2009
Accepted
22 May 2009
First published
09 Jun 2009

Chem. Commun., 2009, 4293-4295

Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis

A. J. Robinson, B. J. van Lierop, R. D. Garland, E. Teoh, J. Elaridi, J. P. Illesinghe and W. R. Jackson, Chem. Commun., 2009, 4293 DOI: 10.1039/B909056H

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