Issue 28, 2009
From the journal:

Chemical Communications

Probing a sialyltransferase’s recognition domain to prepare α(2,8)-linked oligosialosides and analogs†

Ping Zhang,a   Amir J. Zuccolo,a   Wenling Li,a   Ruixiang Blake Zhenga  and  Chang-Chun Ling*a  

* Corresponding authors

a Alberta Ingenuity Centre for Carbohydrate Science, Department of Chemistry, University of Calgary, 2500, University Drive NW, Calgary, Alberta, Canada
E-mail: ccling@ucalgary.ca
Fax: +1 403-289-9488
Tel: +1 403-220-2768

Abstract

We report the first observation that a monosialyl residue is the essential structural element recognized by the enzyme CST-II; this has resulted in an attractive route to synthesize a series of α(2,8)-linked oligosialic acids and their thioanalogs in one step.

Graphical abstract: Probing a sialyltransferase’s recognition domain to prepare α(2,8)-linked oligosialosides and analogs

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Article information

DOI
https://doi.org/10.1039/B908933K
Article type
Communication
Submitted
05 May 2009
Accepted
01 Jun 2009
First published
19 Jun 2009

Chem. Commun., 2009, 4233-4235

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Probing a sialyltransferase’s recognition domain to prepare α(2,8)-linked oligosialosides and analogs

P. Zhang, A. J. Zuccolo, W. Li, R. Blake Zheng and C. Ling, Chem. Commun., 2009, 4233 DOI: 10.1039/B908933K

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