Issue 22, 2009

Palladium-catalyzed amidation–hydrolysis reaction of gem-dihaloolefins: efficient synthesis of homologated carboxamides from ketones

Abstract

A simple and efficient palladium-catalyzed amidation–hydrolysis reaction has been developed to afford N-aryl monosubstituted carboxamides in good to excellent yields from easily accessible ketone-derived gem-dihaloolefins and aryl amines.

Graphical abstract: Palladium-catalyzed amidation–hydrolysis reaction of gem-dihaloolefins: efficient synthesis of homologated carboxamides from ketones

Supplementary files

Article information

Article type
Communication
Submitted
11 Mar 2009
Accepted
16 Apr 2009
First published
08 May 2009

Chem. Commun., 2009, 3246-3248

Palladium-catalyzed amidation–hydrolysis reaction of gem-dihaloolefins: efficient synthesis of homologated carboxamides from ketones

W. Ye, J. Mo, T. Zhao and B. Xu, Chem. Commun., 2009, 3246 DOI: 10.1039/B904991F

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