Issue 22, 2009
From the journal:

Chemical Communications

Colorimetric detection of microRNA and RNase H activity in homogeneous solution with cationic polythiophene derivative†

Yali Zhang,ab   Zhengping Li,*a   Yongqiang Chenga  and  Xuechong Lva  

* Corresponding authors

a Key Laboratory of Medicine Chemistry and Molecular Diagnosis, Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei Province, P. R. China
E-mail: lzpbd@hbu.edu.cn
Fax: +86 312 5079403

b College of Sciences, Hebei University of Science and Technology, Shijiazhuang 050018, Hebei Province, P. R. China

Abstract

A colorimetric assay for convenient detection of miRNA and RNase H activity was established in a homogeneous and label-free manner based on conformational and colorimetric changes of a polythiophene derivative (PMNT) in the duplex of DNA/PMNT and triplex of DNA/miRNA/PMNT.

Graphical abstract: Colorimetric detection of microRNA and RNase H activity in homogeneous solution with cationic polythiophene derivative

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Article information

DOI
https://doi.org/10.1039/B904579A
Article type
Communication
Submitted
06 Mar 2009
Accepted
20 Apr 2009
First published
05 May 2009

Chem. Commun., 2009, 3172-3174

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Colorimetric detection of microRNA and RNase H activity in homogeneous solution with cationic polythiophene derivative

Y. Zhang, Z. Li, Y. Cheng and X. Lv, Chem. Commun., 2009, 3172 DOI: 10.1039/B904579A

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