Issue 20, 2009

Enantioselective total synthesis of the indole alkaloid 16-episilicine

Abstract

The first total synthesis of (−)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.

Graphical abstract: Enantioselective total synthesis of the indole alkaloid 16-episilicine

Supplementary files

Article information

Article type
Communication
Submitted
05 Mar 2009
Accepted
18 Mar 2009
First published
03 Apr 2009

Chem. Commun., 2009, 2935-2937

Enantioselective total synthesis of the indole alkaloid 16-episilicine

M. Amat, B. Checa, N. Llor, E. Molins and J. Bosch, Chem. Commun., 2009, 2935 DOI: 10.1039/B904521J

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