Issue 20, 2009
From the journal:

Chemical Communications

Enantioselective total synthesis of the indole alkaloid 16-episilicine†

Mercedes Amat,*a   Begoña Checa,a   Núria Llor,a   Elies Molinsb  and  Joan Bosch*a  

* Corresponding authors

a Laboratory of Organic Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, Spain
E-mail: amat@ub.edu; joanbosch@ub.edu
Fax: +34 93 402 45 39
Tel: +34 93 402 45 38

b Institut de Ciència de Materials (CSIC), Campus UAB, 08193-Cerdanyola, Spain

Abstract

The first total synthesis of (−)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.

Graphical abstract: Enantioselective total synthesis of the indole alkaloid 16-episilicine

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Article information

DOI
https://doi.org/10.1039/B904521J
Article type
Communication
Submitted
05 Mar 2009
Accepted
18 Mar 2009
First published
03 Apr 2009

Chem. Commun., 2009, 2935-2937

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Enantioselective total synthesis of the indole alkaloid 16-episilicine

M. Amat, B. Checa, N. Llor, E. Molins and J. Bosch, Chem. Commun., 2009, 2935 DOI: 10.1039/B904521J

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