Issue 22, 2009
From the journal:

Chemical Communications

The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides†

Nan Zhang,ab   Chunyan Tan,a   Puqin Cai,a   Peizhuo Zhang,c   Yufen Zhaob  and  Yuyang Jiang*ad  

* Corresponding authors

a Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, P.R. China
E-mail: jiangyy@sz.tsinghua.edu.cn

b Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P.R. China

c Shanghai GenePharma Co. Ltd, 1011 Halley Road, Z.-J. High Tech Park, Shanghai, P.R. China

d School of Medicine, Tsinghua University, Beijing, P.R. China

Abstract

Hypoxia-activated pro-oligonucleotides were synthesized through the commercial phosphoramidite method, and could be readily cleaved to form normal oligos with good hypoxia selectivity in vitro under the effect of reductases, as well as in tumor cell extract.

Graphical abstract: The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides

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Article information

DOI
https://doi.org/10.1039/B903331A
Article type
Communication
Submitted
17 Feb 2009
Accepted
27 Mar 2009
First published
23 Apr 2009

Chem. Commun., 2009, 3216-3218

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The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides

N. Zhang, C. Tan, P. Cai, P. Zhang, Y. Zhao and Y. Jiang, Chem. Commun., 2009, 3216 DOI: 10.1039/B903331A

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