Issue 48, 2009
From the journal:

Chemical Communications

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes†

Gavin Collie,a   Anthony P. Reszka,a   Shozeb M. Haider,a   Valérie Gabelica,b   Gary N. Parkinsona  and  Stephen Neidle*a  

* Corresponding authors

a Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29–39 Brunswick Square, London, UK
E-mail: stephen.neidle@pharmacy.ac.uk

b Mass Spectrometry Laboratory, GIGA-Research, University of Liège, Belgium

Abstract

Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes.

Graphical abstract: Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

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Article information

DOI
https://doi.org/10.1039/B901889A
Article type
Communication
Submitted
29 Jan 2009
Accepted
24 Oct 2009
First published
13 Nov 2009

Chem. Commun., 2009, 7482-7484

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Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

G. Collie, A. P. Reszka, S. M. Haider, V. Gabelica, G. N. Parkinson and S. Neidle, Chem. Commun., 2009, 7482 DOI: 10.1039/B901889A

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