A perfect double role of CF3 groups in activating substrates and stabilizing adducts: the chiral Brønsted acid-catalyzed direct arylation of trifluoromethylketones

Jing Nie; Guang-Wu Zhang; Lian Wang; Aiping Fu; Yan Zheng; Jun-An Ma

doi:10.1039/B900474B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A perfect double role of CF₃ groups in activating substrates and stabilizing adducts: the chiral Brønsted acid-catalyzed direct arylation of trifluoromethylketones†

Jing Nie,^a Guang-Wu Zhang,^a Lian Wang,^a Aiping Fu,^b Yan Zheng^a and Jun-An Ma*^ac

Author affiliations

* Corresponding authors

^a Department of Chemistry, Tianjin University, China
E-mail: majun_an68@tju.edu.cn
Fax: +86 22 27403475
Tel: +86 22 27402903

^b Institute for Computational Science and Engineering, Qingdao University, Shandong, China

^c State Key Laboratory of Elemento-Organic Chemistry, Nankai University, China

Abstract

A direct and efficient Brønsted acid-promoted arylation of tri- and difluoromethyl ketones, as well perfluoroalkyl ketones, has been developed; good to excellent enantioselectivities (up to 99% ee) were achieved.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/B900474B
Article type: Communication
Submitted: 09 Jan 2009
Accepted: 16 Feb 2009
First published: 09 Mar 2009

Download Citation

Chem. Commun., 2009, 2356-2358

Permissions

Request permissions

A perfect double role of CF₃ groups in activating substrates and stabilizing adducts: the chiral Brønsted acid-catalyzed direct arylation of trifluoromethylketones

J. Nie, G. Zhang, L. Wang, A. Fu, Y. Zheng and J. Ma, Chem. Commun., 2009, 2356 DOI: 10.1039/B900474B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications