Peptide- and protein-mediated assembly of heparinized hydrogels
Abstract
Polymeric hydrogels have demonstrated significant promise in biomedical applications such as drug delivery and tissue engineering. A continued direction in hydrogel development includes the engineering of the biological responsiveness of these materials, via the inclusion of cell-binding domains and enzyme-sensitive domains. Ligand–receptor interactions offer additional opportunities in the design of responsive hydrogels, and strategies employing